NooCube Review 2026
James BevanUpdated October 23, 2026
NooCube is the caffeine-free brain supplement that turns up in many lists of the best nootropics. But do 12 ingredients in two capsules reach the amounts the research used, and is the 60-day guarantee as simple as it sounds? To find out, we've checked all 12 amounts against the published studies, read both of NooCube's refund pages, and looked at what expert reviewers and buyers say.
Quick verdict
- Price per serving$2.17
- Doses in range1 of 9
- CaffeineNone
- Money-back guarantee60 days
- Third-party testingUnverified, no report published
- Servings per bottle30
Buying four of these ingredients as separate bottles, at the doses studies used, costs $1.22 a day less. See the list.
A better-rated alternative
- VyvamindAudit rating 6.4/10
2 of 4 ingredients at studied amounts
Shares 2 ingredients with NooCube
Check price$2.33 a day
3.9/5 from 79 Amazon buyers
We may earn a commission from links on this page, at no extra cost to you. How we make money
In this review
What's good, and what isn't
Pros
- Theanine (100 mg) is within the doses used in studies that showed a benefit
- Bacopa (250 mg) and the marigold extract (20 mg) reach their benchmark amounts, although in extracts we can't match to the trials
- Fortune chose it as its focus pick with 4 out of 5, and Nootropics Expert rates it 4.5 out of 5 for effectiveness
Cons
- Ginseng is 20 mg against 200 mg in its studies, and tyrosine and resveratrol are well short too
- The 60-day guarantee keeps a 5% handling fee, and NooCube's two refund pages give different terms
- Buyers rate it 2.8 out of 5 across 16 ratings on Trustpilot, all for the UK store, and it isn't sold on Amazon
Why NooCube scored 3.7 out of 10
- Dose fit40%26
Theanine reaches the bottom of its studied range. The marigold extract and bacopa reach theirs in milligrams with extracts we can't match to the trials, so they earn half credit. Tyrosine, ginseng and resveratrol fall short, by 135.7 mg to 1,750 mg, and six more have no studied range on file, so they earn nothing for dose.
- Evidence30%24
Evidence only counts in full when the dose matches the studies. Bacopa's research is strong, but we can't confirm NooCube's extract matches the trials', and the ginseng, tyrosine and resveratrol trials used several times NooCube's amounts.
- Transparency20%95
All 12 amounts are printed, with extract ratios and the bacoside strength, and there are no blends. The marigold extract is listed by weight, not by how much lutein and zeaxanthin it contains.
- Testing10%0
The homepage says the brand has spent "100s of $1000s of dollars in 3rd party testing," but we found no lab report on the site, no published human trial of NooCube, and no NSF listing.
Worked out under method audit-v2.0. How the rating is built
Score history
Oct 23, 2026 First audit published
We checked the label, compared each dose with the human research and published the review.
NooCube's 3.7 rests largely on printing all 12 amounts, although only six of them have research ranges we can compare. Of those six, theanine just reaches the bottom of its range, and the marigold extract and bacopa reach theirs in milligrams but in extracts we can't match to the trials, so they earn half credit. Tyrosine, ginseng and resveratrol fall short by 135.7 mg to 1,750 mg, which is where most of the points go, and the other six earn nothing for dose because we have no research range on file.
The homepage talks about spending "100s of $1000s of dollars in 3rd party testing," but we couldn't find a lab report, a published human trial or an NSF listing, so verification scores zero. We'd happily raise the score for a bacopa extract confirmed to match the trials, ginseng, tyrosine and resveratrol at the amounts the studies used, and a lab report you can read.
The claims, checked
The version 3.0 facts label on the site matches all 12 amounts in our records.2 Two capsules make a serving, with 30 servings in the 60-capsule bottle. One oddity is the bacopa, which the homepage lists as a "12:1" extract while the label gives only the 20 percent bacoside figure.1
The homepage recommends two capsules daily with water, preferably in the morning, with or without food. The other ingredients are microcrystalline cellulose, a hypromellose capsule, maltodextrin, silica and vegetable magnesium stearate. There's no caffeine, and the homepage describes version 3.0 as suitable for vegetarians. The bottle doesn't claim to be gluten-free, although the homepage says the old oat straw was dropped because it contained gluten.1
“Price Per Serving** $1.29”
PartlyThe homepage's comparison table gives this figure, with a footnote saying it's "based on biggest saving packages."1 Bought one time, even the five-bottle pack works out a cent higher, and only if you pay for five months up front. On subscription the five-bottle pack does come in under it, so the figure is reachable, but only on the three- or five-bottle subscription. A single bottle costs $2.17 a serving.
“Choline From Vita-choline® 250 Mg”
Partly“A randomized, double-blind, placebo study of 59 healthy individuals were each given Lutemax® 2020 for a full 12 months.”
Doesn't hold upThe homepage's "Confirmed Study" box says this, next to the claim that Lutemax 2020 is "proven to improve attention, verbal memory, processing speed, and even stress response."1 The 59-person trial in its source list ran for six months, not 12, in adults aged 18 to 25 taking 13 or 27 mg of the carotenoids a day.19
NooCube lists 20 mg of marigold extract without the lutein and zeaxanthin amounts,2 so we can't tell whether a serving matches what those volunteers took.
“We have spent 100s of $1000s of dollars in 3rd party testing and re-testing to prove that our formula works with stellar results.”
UnverifiedThe statement appears in the homepage's guarantee section,1 but we found no lab report on the site, and the usual addresses for one return a not-found page.
A PubMed search finds no human trial of NooCube.6 The one paper that mentions it is a 2021 lab-dish study that tested 21 memory supplements against brain plaque and tangle proteins, written by a company comparing them with its own product, and it predates version 3.0.37 NSF doesn't list NooCube either.5 Whatever testing sits behind that statement, it hasn't been published.
“Our formula doesn't require a doctor's prescription and is easy-to-digest with no known side effects.”
Doesn't hold up“You are still covered by our 100%, 60-day money-back guarantee, which you won't find anywhere else.”
PartlyThe homepage makes this promise,1 while the guarantee page asks you to email support@noocube.com for a return authorization. You then return any unopened products along with the used ones within 60 days, and the refund covers the product price minus a 5 percent handling fee, with shipping excluded.3
The separate refund-policy page allows 67 days. It asks for the first two empty bottles plus any unopened ones on multi-bottle orders, and only "the unused bottles" on a single order, with no handling fee mentioned.4 Mind Lab Pro and Qualia Mind also offer money-back guarantees, so "you won't find anywhere else" is only partly true.
What's inside, audited
9 ingredients checked, 1 within range, 3 short, 2 above the range or at half credit, 3 with no studied range.
Within range (L-theanine). Short (L-tyrosine, ginseng, resveratrol). Above the range or at half credit (lutein and zeaxanthin, bacopa). No studied range (choline bitartrate, cat's claw, pterostilbene).
Moderate evidence
Doses used in studies that showed a benefit
NooCube has 100 mg, the lowest single dose used in studies that showed a benefit.42
Study dose benchmark from Dassanayake 2023, One dose of 100, 200 or 400 mg42
Theanine provides 100 mg, the bottom of its research range. A 2026 analysis of 31 randomized trials found faster choice reaction time after one 200 mg dose.13 In a four-week trial of 30 adults on 200 mg a day, verbal fluency and executive function scores rose, but only verbal fluency, in the people who started lowest, beat placebo.14 NooCube gives you half the 200 mg most of the research used.
std. 20% bacosides · Strong evidence
Doses used in studies that showed a benefit
NooCube has 250 mg, the lowest daily dose used in studies that showed a benefit, but the label doesn't confirm the form or extract those studies tested, so it earns half credit.41
Study dose benchmark from Raghav 2006, 125 mg twice a day, 12 weeks41
Bacopa provides 250 mg of an extract with 20 percent bacosides, while the 300 mg extracts in the 12-week trials contained 40 to 55 percent.1011 That gives you 50 mg of bacosides a serving, against 120 mg or more in the studies, assuming the two percentages were measured the same way, so we can't confirm the extract matches the trials'. Single doses of 320 mg and 640 mg improved scores on two attention tasks within two hours in a 2014 trial of 17 healthy adults.44 A 2014 analysis of nine trials lasting 12 weeks or more found faster attention on a trail-making test and choice reaction time.12 The trial in 98 adults over 55 also recorded stomach cramps, nausea and more frequent bowel movements with bacopa than placebo.11
Lutemax 2020® · Moderate evidence
Doses used in studies that showed a benefit
NooCube has 20 mg, inside the 12 mg to 27 mg used in studies that showed a benefit, but the label doesn't confirm the form or extract those studies tested, so it earns half credit.20
Study dose benchmark from Lopresti 2022, 10 mg lutein and 2 mg zeaxanthin a day, 6 months20
Lutein and zeaxanthin come from 20 mg of marigold flower extract sold as Lutemax 2020. That's the weight of the extract, and the label doesn't give the lutein and zeaxanthin amounts inside it.2 The trial the homepage relies on gave 59 young adults 13 or 27 mg a day of the carotenoids themselves for six months, and memory, attention and processing speed improved.19
A 2022 trial gave 90 adults aged 40 to 75 with memory complaints 10 mg of lutein and 2 mg of zeaxanthin daily for six months. Visual memory and learning improved over placebo, but the other tests didn't change.20 Both studies measured the effect after six months.
Tyrosine provides 250 mg, 1,750 mg less than the smallest amount that helped in studies, where doses were measured in grams. Working memory during multitasking improved in a 1999 study using 150 mg per kilogram of body weight, or about 10 g for an average adult.15 Higher doses weren't always better, as a 2017 study in older adults found slightly worse working memory after single doses of 100 to 200 mg per kilogram.16
8:1 concentrate · Preliminary evidence
Doses used in studies that showed a benefit
NooCube has 20 mg. The study dose we use as this ingredient's benchmark is 200 mg, so it's 180 mg short.17
Study dose benchmark from Reay 2005, 200 or 400 mg, single dose17
Ginseng comes as 20 mg of an 8:1 concentrate, which the label and homepage both call equivalent to 160 mg of ginseng powder.12 The trials used 200 mg and 400 mg of G115, an extract made to a set strength rather than powder, so the bottle's 20 mg is 180 mg short of the smaller dose. Among 30 young adults, one 200 mg dose improved a mental arithmetic task and reduced mental fatigue.17 Over eight days, 400 mg improved calmness and arithmetic, but 200 mg slowed arithmetic.18
Resveratrol provides 14.3 mg. A 14-week trial in 80 women after menopause found that resveratrol improved verbal memory and overall cognitive performance.21 The same team's 24-month trial gave 125 women 75 mg twice a day,22 and that 150 mg a day is the benchmark we use, so NooCube's amount is less than a tenth of it. A 2014 study matched 23 older adults taking 200 mg a day for 26 weeks with 23 on placebo and found better word recall.23
Also on the label are choline bitartrate 100 mg, cat's claw 175 mg, pterostilbene 140 mcg. We have no verified human dose range on file for these, so they stay in the formula count, earn nothing for dose and only a small fixed credit for evidence, which lowers the score.
Also on the label are vitamin B1 1.1 mg, vitamin B12 2.5 mcg, biotin 50 mcg. These have no cognitive dose range for people who aren't deficient, so they don't count toward the formula score.
Cat's claw, choline and pterostilbene have no research range on file, so they earn nothing for dose and only a small fixed credit for evidence. The cat's claw studies we found used lab dishes, mice and rats,2425 and the only human trial we found for pterostilbene looked at safety at 100 to 250 mg a day, while NooCube provides 140 mcg.26
Choline comes from 250 mg of VitaCholine choline bitartrate and amounts to 100 mg, or 18 percent of the 550 mg Daily Value.229 The B vitamins sit close to or above their Daily Values, with B1 at 92 percent, B12 at 104 percent and biotin at 167 percent. B12 hasn't been shown to help memory in people who aren't low in it,2728 and B1 and biotin have no research range on file.
Every amount is printed, along with the bacoside strength and extract ratios, so you can check these comparisons yourself. The exception is the marigold extract, whose weight is given without the amounts of its lutein and zeaxanthin.
Compare it yourself
NooCube against its closest matches
| Product |  NooCubeThis review |  Vyvamind |  Alpha Brain |  Mind Lab Pro |
|---|---|---|---|---|
| Audit rating | 3.7/10 | 6.4/10 | 3.7/10 | 5.5/10 |
| Price per serving | $2.17 | $2.33 | $1.78 | $2.30 |
| Doses of NooCube's ingredients | ||||
| Choline (Bitartrate) | 100 mgVitaCholine®No cognitive dose range | Not in formula | Not in formula | Not in formula |
| L-Tyrosine | 250 mg1,750 mg below the study dose benchmark | 300 mg1,700 mg below the study dose benchmark | In a blend, dose not printed | 142 mg175 mg N-acetyl L-tyrosine on the label1,858 mg below the study dose benchmark |
| Cat's Claw | 175 mg4:1 concentrateNo cognitive dose range | Not in formula | 350 mgbark extractNo cognitive dose range | Not in formula |
| L-Theanine | 100 mgAt or above the study dose benchmark | 150 mgAt or above the study dose benchmark | In a blend, dose not printed | 100 mgAt or above the study dose benchmark |
| Trans-Resveratrol | 14 mg136 mg below the study dose benchmark | Not in formula | Not in formula | Not in formula |
| Pterostilbene | 140 mcgNo cognitive dose range | Not in formula | In a blend, dose not printed | Not in formula |
| Panax Ginseng | 20 mg8:1 concentrate180 mg below the study dose benchmark | Not in formula | Not in formula | Not in formula |
| Lutein + Zeaxanthin | 20 mgLutemax 2020®Half credit | Not in formula | Not in formula | Not in formula |
| Bacopa Monnieri | 250 mgstd. 20% bacosidesHalf credit | Not in formula | 100 mgleaf and stem extract, standardization not stated150 mg below the study dose benchmark | 150 mgfull-spectrum, 24% bacosides100 mg below the study dose benchmark |
The products that share the most cognitive ingredients with NooCube are shown first. Any product sharing at least two can be added.
Mind Lab Pro is the obvious comparison, since it's also caffeine-free. It shares bacopa, theanine and tyrosine with NooCube, then adds 250 mg of citicoline at an amount used in studies, plus 100 mg of phosphatidylserine. Its bacopa is 150 mg, though, against NooCube's 250 mg. At $2.30 a serving direct, it costs 13 cents more than a single bottle of NooCube.
Nooceptin is another caffeine-free option at $2.23 a serving from its own site, with 200 mg of theanine and 200 mg of ginseng against NooCube's 100 mg and 20 mg. Alpha Brain comes up next to NooCube in a lot of searches, but it hides most of its amounts in blends, so the two can't be compared dose for dose. Our Alpha Brain review covers what its label does and doesn't tell you.
NooCube's case is the multi-bottle price, no caffeine and a label you can check. If you'd rather have amounts closer to the studies, Mind Lab Pro and Nooceptin cost about the same as a single bottle.
Price and where to buy
NooCube sells direct from noocube.com, where one bottle cost $64.99 when we checked, or $2.17 a serving.1 The three- and five-bottle packs, sold as "2 BOTTLES + 1 FREE" and "3 BOTTLES + 2 FREE," bring the cost a serving down, and a subscription takes 15 percent off any of them. The store's banner reads "FREE SHIPPING OVER $79.99," so a single bottle pays for shipping and the bigger packs don't. Orders are capped at five bottles per household.
You won't find it on Amazon from the brand. NooCube's Amazon storefront carries only NooCube NAD+, and the one listing called Brain Productivity belongs to another brand.7 That also means there's no Amazon rating to go on. NooCube's site shows a handful of named testimonials rather than a review count, Trustpilot has no reviews of noocube.com, and the 16 for the UK store are the only independent ones we found.89
- noocube.com direct
- Listed price
- $64.99
- Per serving
- $2.17
- Status
- In stock
What studied amounts cost separately
This section compares NooCube with buying each of its ingredients on its own, one bottle per ingredient, at the dose the studies started from. We've chosen each bottle for quality rather than the lowest price. Theanine is the one ingredient where NooCube already reaches the studies, and the marigold extract and bacopa reach theirs in extracts we can't match to the trials.
L-tyrosine 2,000 mg
No pick. The best single we've audited scores 5.7, and we only pick at 6.0 or above.
Ginseng 200 mg
No pick. The best single we've audited scores 5.5, and we only pick at 6.0 or above.
Lutein and zeaxanthin 12 mg
1 capsule of 24 mg, rounded up
Bought separately, without L-tyrosine and ginseng
$0.94 a day
$28.30 for 30 servings
NooCube at noocube.com
$2.17 a day
$64.99 for 30 servings
Buying the other four separately saves $1.22 a day ($36.70 for 30 servings).
The list has the current cost a day for each pick.
What other reviewers say
Innerbody Research
Written review, tried for two weeks · Elsa Whitney · Updated Aug 4, 2024
“And, even though a majority of the ingredients are underdosed when compared to successful studies, this nootropic still has the potential to help some people.”
Fortune Recommends
Roundup entry, one tester for one day · Christina Snyder, reviewed by Jillian Robillard, MS, RD · Updated Oct 6, 2026
“Noocube Brain Productivity is our best nootropics pick for focus because it brings together several of the most commonly studied nootropic ingredients into a straightforward capsule, ideal for a daily routine focused on cognitive sharpness.”
SOMA Analytics
Written review, one tester for a month · Alex Whybrow, fact checked by Jason M and the editorial team · Updated Apr 24, 2024
“NooCube is one of our all-time favorite nootropic supplements. It tops pretty much all of our comparisons, and is also our no.1 rated nootropic overall.”
Illuminate Labs
Written review, ingredient analysis without testing · Calloway Cook, medically reviewed by Auren Weinberg, MD · Updated Jun 21, 2025
“We do not currently recommend Noocube”
Your Inception
Video review (YouTube, 46,800 subscribers) · Sep 20, 2022
Our summary of the video
He took the older formula for a couple of weeks, felt slightly more focused and alert for a few hours, called the price high for the ingredients and doses, and suggests it mainly for people who care about brain health and want a mild lift in focus.
Reviews of version 3.0 are mixed, and the critical ones point to low doses. Innerbody rated it 3.4 out of 5 after two weeks and wrote that "a majority of the ingredients are underdosed when compared to successful studies."31 Nootropics Expert scores it 4.5 out of 5 for effectiveness in its comparison with Mind Lab Pro, but concludes that "Mind Lab Pro's formula is more effective overall in enhancing cognitive function."40
Fortune chose it as its focus pick with 4 out of 5, although its tester took it for one day and noticed no change.32 SOMA Analytics gives no score but calls it its "no.1 rated nootropic overall" after a month's trial.33 Illuminate Labs analyzed the label without taking it and doesn't recommend NooCube in its key takeaway, although its conclusion calls it "somewhat likely to have a nootropic effect."34 Your Inception's video and WholisticResearch's 4.8 out of 5 review both describe the older ingredients with alpha-GPC, so their ingredient notes don't match the current bottle.3536
What buyers report
What buyers wrote
“Unfortunately didn’t notice any difference at all and requested to return the items.”
“For me it didn't work, I did not notice any difference whatsoever in mental speed, focus or memory.”
Safety notes
With no caffeine, NooCube won't add to what you get from coffee. Bacopa is the ingredient most likely to bother you, through an upset stomach, so taking it with food is worth trying, although no trial compared the two and the homepage says you can take it either way.111
Two of the smaller ingredients matter if you take medication. Ginseng might lower blood sugar and interact with some medicines, so ask your doctor first if you have diabetes,38 and cat's claw might interact with blood thinners and blood pressure drugs.39 No published study covers this combination. Speak to a doctor first if you take medication, are pregnant or breastfeeding, or have a health condition. We're researchers, not doctors.
Final thoughts
NooCube is a caffeine-free capsule with all 12 amounts printed, which is more than many brain supplements manage. Only theanine reaches the bottom of its research range in full, though, and while the marigold extract and bacopa get there, it's in extracts we can't match to the trials. Ginseng, tyrosine and resveratrol come in 135.7 mg to 1,750 mg below the studies, and nothing published backs up the talk of testing.
If the five-bottle price and a stimulant-free label are what you're after, NooCube does that, and the guarantee lets you try it. If you want amounts closer to the research, Mind Lab Pro or Nooceptin get you there for about the same as one bottle. Whichever you choose, read both of NooCube's refund pages first and keep the empty bottles, and bear in mind that the 60-day guarantee ends long before the six months the lutein trials ran.
FAQ
Does NooCube contain caffeine?
How many capsules do you take?
Is NooCube clinically proven?
Does NooCube have a money-back guarantee?
Is NooCube third-party tested?
What changed in NooCube version 3.0?
Is NooCube sold on Amazon?
How long does NooCube take to work?
NooCube or Mind Lab Pro?
Sources
44 sources cited
- NooCube. Brain Productivity homepage and order page. Ingredient descriptions, comparison table with "Price Per Serving** $1.29" ("**based on biggest saving packages"), one-time prices of $64.99 (1 bottle), $129.99 (3 bottles) and $194.99 (5 bottles), subscription prices of $55.24, $110.49 and $165.74, FAQ with directions and safety answer, "Confirmed Study" box giving the Lutemax trial as "a full 12 months", "FREE SHIPPING OVER $79.99", "MAX 5 BOTTLES PER HOUSEHOLD". Accessed Oct 22, 2026. noocube.com
- NooCube. Supplement facts label, USA version 3.0. 2 capsules a serving, 30 servings. Accessed Oct 22, 2026. noocube.com label image
- NooCube. Guarantee page. 60 days, unopened products returned with the used products, refund of the product price minus a 5% handling fee, shipping excluded. Accessed Oct 22, 2026. noocube.com/pages/guarantee
- NooCube. Refund policy. Headed 60-day guarantee, returns accepted within 67 days, multi-bottle orders return the first two empty bottles and any unopened bottles, single orders return "the unused bottles", no handling fee stated. Accessed Oct 22, 2026. noocube.com/policies/refund-policy
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- Amazon search for NooCube with delivery to New York 10001. The NooCube storefront sells only NooCube NAD+, and the one "Brain Productivity" listing is from another brand. Checked Oct 19, 2026. amazon.com
- Trustpilot reviews of noocube.com. No reviews. Checked Oct 22, 2026. trustpilot.com
- Trustpilot reviews of noocube.co.uk, NooCube's UK store. 2.8 from 16 reviews, 94% one-star, two reviews in the last 12 months. Checked Oct 22, 2026. trustpilot.com
- Stough C, et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology, 2001. 300 mg a day of Keenmind as published, for 12 weeks. PMID 11498727
- Morgan A, Stevens J. Does Bacopa monnieri improve memory performance in older persons? Results of a randomized, placebo-controlled, double-blind trial. J Altern Complement Med, 2010. 300 mg a day of BacoMind for 12 weeks, 98 adults over 55 started and 81 finished, stomach and bowel side effects. PMID 20590480
- Kongkeaw C, et al. Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. J Ethnopharmacol, 2014. 9 trials of 12 weeks or more, 437 participants analysed. PMID 24252493
- Gerolymos C, et al. Cognitive and affective effects of L-theanine. A systematic review and meta-analysis of 31 randomized trials. Mol Psychiatry, 2026. PMID 42410082
- Hidese S, et al. Effects of L-theanine administration on stress-related symptoms and cognitive functions in healthy adults. A randomized controlled trial. Nutrients, 2019. 200 mg a day for 4 weeks, 30 adults. PMID 31623400
- Thomas JR, Lockwood PA, Singh A, Deuster PA. Tyrosine improves working memory in a multitasking environment. Pharmacol Biochem Behav, 1999. 150 mg/kg in 20 adults. PMID 10548261
- van de Rest O, et al. Dose-dependent effects of oral tyrosine administration on plasma tyrosine levels and cognition in aging. Nutrients, 2017. 100, 150 or 200 mg/kg, 17 adults aged 60 to 75. PMID 29168741
- Reay JL, Kennedy DO, Scholey AB. Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity. J Psychopharmacol, 2005. Single 200 and 400 mg doses, 30 young adults. PMID 15982990
- Reay JL, Scholey AB, Kennedy DO. Panax ginseng (G115) improves aspects of working memory performance and subjective ratings of calmness in healthy young adults. Hum Psychopharmacol, 2010. 200 and 400 mg a day for 8 days, 30 young adults. PMID 20737519
- Stringham NT, Holmes PV, Stringham JM. Effects of macular xanthophyll supplementation on brain-derived neurotrophic factor, pro-inflammatory cytokines, and cognitive performance. Physiol Behav, 2019. 13 or 27 mg a day of lutein and zeaxanthins for 6 months, 59 adults aged 18 to 25. PMID 31425700
- Lopresti AL, Smith SJ, Drummond PD. The effects of lutein and zeaxanthin supplementation on cognitive function in adults with self-reported mild cognitive complaints. Front Nutr, 2022. 10 mg lutein and 2 mg zeaxanthin a day for 6 months, 90 adults aged 40 to 75. PMID 35252311
- Evans HM, Howe PR, Wong RH. Effects of resveratrol on cognitive performance, mood and cerebrovascular function in post-menopausal women. A 14-week randomised placebo-controlled intervention trial. Nutrients, 2017. 80 women aged 45 to 85. PMID 28054939
- Thaung Zaw JJ, Howe PR, Wong RH. Long-term effects of resveratrol on cognition, cerebrovascular function and cardio-metabolic markers in postmenopausal women. A 24-month randomised, double-blind, placebo-controlled, crossover study. Clin Nutr, 2021. 75 mg twice a day, 125 women aged 45 to 85. PMID 32900519
- Witte AV, et al. Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults. J Neurosci, 2014. 200 mg a day for 26 weeks, 46 adults. PMID 24899709
- Snow AD, et al. The Amazon rain forest plant Uncaria tomentosa (cat's claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles. Sci Rep, 2019. Laboratory and mouse study. PMID 30728442
- Castilhos LG, et al. Uncaria tomentosa improves cognition, memory and learning in middle-aged rats. Exp Gerontol, 2020. Animal study. PMID 32628974
- Riche DM, et al. Analysis of safety from a human clinical trial with pterostilbene. J Toxicol, 2013. 50 or 125 mg twice a day, 100 to 250 mg a day, in adults with high cholesterol. PMID 23431291
- Markun S, et al. Effects of vitamin B12 supplementation on cognitive function, depressive symptoms, and fatigue. A systematic review, meta-analysis, and meta-regression. Nutrients, 2021. 16 trials, 6,276 participants, no effect on cognition in people without advanced neurological disorders. PMID 33809274
- Clarke R, et al. Effects of homocysteine lowering with B vitamins on cognitive aging. Meta-analysis of 11 trials with cognitive data on 22,000 individuals. Am J Clin Nutr, 2014. PMID 24965307
- NIH Office of Dietary Supplements. Choline fact sheet for health professionals. Daily Value 550 mg. Accessed Oct 20, 2026. ods.od.nih.gov
- NooCube. Older UK label in the store's product images. Oat straw extract 150 mg, alpha-GPC 50 mg and Huperzia serrata 20 mg (0.5% huperzine A), no ginseng or choline bitartrate. Accessed Oct 20, 2026. cdn.shopify.com
- Whitney E. Noocube review. Innerbody Research, updated Aug 4, 2024. Editor's Rating 3.40 on a five-star graphic, covers version 3.0. Accessed Oct 22, 2026. innerbody.com
- Snyder C. Best nootropics. Fortune Recommends, published Feb 13, 2026, updated Oct 6, 2026, medically reviewed by Jillian Robillard, MS, RD, LDN, CSSD. NooCube is the focus pick, Fortune score 4 out of 5, one tester for one day. Accessed Oct 22, 2026. fortune.com
- Whybrow A. NooCube review. SOMA Analytics, updated Apr 24, 2024. No score, one tester for a month. Accessed Oct 22, 2026. soma-analytics.com
- Cook C. Noocube review. Illuminate Labs, updated Jun 21, 2025, medically reviewed by Auren Weinberg, MD. No score, not tested. Accessed Oct 22, 2026. illuminatelabs.org
- Your Inception. 30 Days of NOOCUBE testing - Watch Before You Buy This! YouTube, Sep 20, 2022. Older formula. Accessed Oct 22, 2026. youtube.com
- Kovacs J. NooCube review. WholisticResearch, published Sep 11, 2026. Overall rating 4.8 out of 5, lists the older formula with alpha-GPC, oat straw and Huperzia serrata. Accessed Oct 22, 2026. wholisticresearch.com
- Snow AD, Cummings JA, Tanzi RE, Lake T. In vitro comparison of major memory-support dietary supplements for their effectiveness in reduction/inhibition of beta-amyloid protein fibrils and tau protein tangles. Sci Rep, 2021. Lab study of 21 products including NooCube, by authors from Cognitive Clarity Inc., which makes one of the products compared. PMID 33589649
- National Center for Complementary and Integrative Health. Asian ginseng, usefulness and safety. Might lower blood sugar, might interact with certain medications. Accessed Oct 22, 2026. nccih.nih.gov
- National Center for Complementary and Integrative Health. Cat's claw, usefulness and safety. Theoretical interactions with anticoagulant, antiplatelet and blood pressure drugs. Accessed Oct 22, 2026. nccih.nih.gov
- Tomen D. NooCube vs Mind Lab Pro. Nootropics Expert, Aug 14, 2025. NooCube rated effectiveness 4.5/5, safety 4/5, transparency 5/5, satisfaction guarantee 5/5. Accessed Oct 22, 2026. nootropicsexpert.com
- Raghav S, et al. Randomized controlled trial of standardized Bacopa monniera extract in age-associated memory impairment. Indian J Psychiatry, 2006. 125 mg twice a day for 12 weeks, improved mental control, logical memory and paired-associate learning. PMID 20703343
- Dassanayake TL, et al. Dose-response effect of L-theanine on psychomotor speed, sustained attention, and inhibitory control. A double-blind, placebo-controlled, crossover study. Nutr Neurosci, 2023. Single doses of 100, 200 or 400 mg, 32 young adults. PMID 36263942
- Colzato LS, Jongkees BJ, Sellaro R, Hommel B. Working memory reloaded. Tyrosine repletes updating in the N-back task. Front Behav Neurosci, 2013. A single 2.0 g dose. PMID 24379768
- Benson S, et al. An acute, double-blind, placebo-controlled cross-over study of 320 mg and 640 mg doses of Bacopa monnieri (CDRI 08) on multitasking stress reactivity and mood. Phytother Res, 2014. 17 healthy adults, single doses. PMID 23788517
Where this data comes from
- Price source
- noocube.com $64.99 for 30 servings
- Third-party testing
- Claimed on the homepage. No lab report published. Not listed by NSF
- How we reviewed it
- Label and evidence audit
Our scoring method, weights, and the rules that keep affiliate money away from scores are documented on the editorial process page.
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