Revive MD Brain+ Review 2026

Brain+ has two ingredients at full strength and a long list that isn't. The 500 mg of Cognizin citicoline is twice the lower dose in its trial, and the 300 mg of rhodiola is the studied type of extract at well over its benchmark. Everything else is short of its studied amount, in an unnamed form, or both, and with seven scored ingredients sharing the formula score, those gaps add up.

That pulls the evidence score down too, because each ingredient's research counts only as far as its dose does. Transparency is decent, with every amount printed, but testing scores zero. Revive posts a certificate for Brain+, but the lab, maker and lot are blacked out, and of the ingredients, it only measures two of the B vitamins.

The label lists 12 ingredients in a 5-capsule serving, 30 servings to a 150-capsule bottle, each with its amount and nothing in a blend.¹ Five capsules is a lot to take at once, and the directions say all five once a day. The product page also carries a California Prop 65 warning for lead.²

Revive's own product data is out of date in places. The store's description, which the page no longer shows, still lists 300 mg of bacopa and 100 mg of ginkgo, and neither is on the label.² The Amazon listing's title and text still name alpha-GPC, from an earlier version of the formula, even though its images show the current label.³

Citicoline and rhodiola are the solid part of the label. The 500 mg of Cognizin matches the higher of the two doses in a 28-day trial in 60 healthy women, where both helped on an attention task.⁴ The rhodiola is 300 mg of root extract at 3 percent rosavins and 1 percent salidroside, the same type of extract as the 170 mg a day that reduced fatigue in night-shift doctors over two weeks.⁵

Saffron and PQQ get half credit each, for different reasons. The 30 mg of saffron matches the 28 mg of affron in a 12-week trial in 202 adults with low mood, two of whose authors work for affron's maker.⁸ The label doesn't name the extract or give a standardization, and saffron extracts aren't interchangeable. The PQQ is the studied disodium salt, but 10 mg is half the 20 mg a day in a 12-week trial in older adults.⁹

Alpha lipoic acid, acetyl-L-carnitine and tyrosine are the furthest off. The 250 mg of alpha lipoic acid is about 40 percent of the 600 mg a day that lowered depression scores in people with diabetes and heart disease.⁶ The 500 mg of acetyl-L-carnitine is a third of the 1,500 mg a day given to people with dementia after strokes.¹⁰ The 500 mg of tyrosine is a quarter of the single 2,000 mg dose in its working memory trial.¹¹

The 400 mcg of lithium, from lithium orotate, is a mineral at a tiny fraction of a prescription dose, so we don't score it, and the same goes for the niacin, B6, folate and B12. The 500 mcg of B12 is about 200 times the daily value, which isn't unusual for a supplement.

Revive MD Brain+ against its closest matches

Shared ingredientsFull formula

Add a product to compare+ Add a productQualia MindMind Lab ProBrain VitaleThesis Stress Reset

Product	BBrain+This review	×Focus Support	×Neutonic Productivity Drink	×Transparent Labs Cognition
Scientific audit	4.9/10	6.5/10	6.7/10	7.8/10
Buyer rating	9.1/10	9.2/10	8.6/10	9.7/10
Price per serving	$2.00	$2.97	$3.00	$1.67
Doses of Brain+'s ingredients
Citicoline	500 mgCognizinAt or above the study dose benchmark	500 mgCognizinAt or above the study dose benchmark	500 mgCognizinAt or above the study dose benchmark	250 mgCognizinAt or above the study dose benchmark
Acetyl-L-Carnitine	500 mgacetyl-L-carnitine HCl1,000 mg below the study dose benchmark	Not in formula	Not in formula	Not in formula
L-Tyrosine	500 mgL-tyrosine1,500 mg below the study dose benchmark	162 mg200 mg N-acetyl L-tyrosine on the label1,838 mg below the study dose benchmark	Not in formula	Not in formula
Rhodiola Rosea	300 mgroot extract, 3% rosavins, 1% salidrosidesAt or above the study dose benchmark	350 mgRhodiolife root extract, 5% rosavins, 1.8% salidrosideAt or above the study dose benchmark	400 mgroot extract, no rosavin or salidroside standardization printedHalf credit	600 mgRhodiolife, 5% rosavins, 1.8% salidrosideAt or above the study dose benchmark
Alpha Lipoic Acid	250 mgalpha lipoic acid350 mg below the study dose benchmark	Not in formula	Not in formula	Not in formula
PQQ	10 mgPQQ disodium salt10 mg below the study dose benchmark	20 mgpyrroloquinoline quinoneHalf credit	Not in formula	Not in formula
Saffron Extract	30 mgflower extract, no standardization statedHalf credit	30 mgflower extract, 2% safranalHalf credit	Not in formula	Not in formula

The products that share the most cognitive ingredients with Brain+ are shown first. Any product sharing at least two can be added.

If citicoline is the reason you're looking at Brain+, Brain Vitale has 250 mg of Cognizin with the same 500 mg of acetyl-L-carnitine for $2.62 a serving. Thesis Stress Reset is the closer match if it's the mood ingredients you want. For rhodiola on its own, a single bottle at its studied amount costs much less, and the list further down prices it.

A one-time bottle costs $59.99 on Revive's site, which is $2.00 a serving, and the subscription takes 25 percent off the first order.²

Revive also sells Brain+ through its own Amazon store.³

• revivesups.com direct

  Listed price

  $59.99

  Per serving

  $2.00

  Status

  Order page live (one-time)

This lists the seven ingredients we score as separate bottles at the amounts their studies started from.

The write-ups that rank for Brain+ mostly describe its 2021 launch formula. PricePlow's, from April 2021, lists 600 mg of a 50 percent alpha-GPC, 250 mg of citicoline and phosphatidylserine,¹³ none of which matches today's label, which has 500 mg of Cognizin citicoline and no alpha-GPC or phosphatidylserine.¹ We found no independent review of the current version.

Revive's FAQ says not to take Brain+ if you're on prescription antidepressants, and to check with your doctor about any other prescription medication.² Lithium is also a prescription drug for bipolar disorder, taken several times a day with regular blood tests,¹⁴ so if you're prescribed it, don't add Brain+ without your doctor, even though the amount here is very small. The label carries a Prop 65 warning for lead, and the certificate measured just under 1 ppm of lead, against its own 2 ppm limit.⁷ If you're pregnant or breastfeeding, ask your doctor first. And if you build it yourself, the saffron pick's label says not to take it if you're pregnant or nursing, and to check with your doctor if you have a bleeding disorder or take medication, including blood thinners. We're researchers, not doctors.

Brain+ gives you a full dose of Cognizin and a properly standardized rhodiola, which are its two best ingredients by some way. The other five scored ingredients are mostly half their studied amounts or less, the saffron extract isn't named, and the certificate doesn't test any of them or say who ran it.

If you like the idea of citicoline and rhodiola with a mix of supporting ingredients in one bottle, and you aren't on antidepressants or lithium, it's a reasonable formula, but there's no refund if it doesn't suit you. If you'd rather get what the research supports, the two strong ingredients are easy to buy on their own.

14 sources cited

1. Revive MD. Brain+ supplement facts image on the product page. 5 capsules a serving, 30 servings, niacin (niacinamide) 100 mg, vitamin B6 (P5P) 20 mg, folate (L-5-MTHF) 200 mcg DFE, vitamin B12 (methylcobalamin) 500 mcg, Cognizin citicoline 500 mg, acetyl-L-carnitine HCl 500 mg, L-tyrosine 500 mg, Rhodiola rosea root extract (3% rosavins, 1% salidrosides) 300 mg, alpha lipoic acid 250 mg, saffron (flower) extract 30 mg, PQQ (as PQQ disodium salt) 10 mg, lithium (as lithium orotate) 400 mcg. Accessed Nov 10, 2026. Label image
2. Revive MD. Brain+ product page. One-time $59.99, subscription $44.99, "26 Verified 4.9 Star Reviews", "GMP certified", "third-party tested" and "physician formulated" badges, a Prop 65 lead warning, "Take five (5) capsules once daily", an FAQ saying not to use it with prescription antidepressants and that there's "no evidence for or against" taking it twice a day, and product data whose description still lists 300 mg of bacopa and 100 mg of ginkgo, which the page doesn't display. Accessed Nov 10, 2026. revivesups.com
3. Amazon. Revive MD Brain+, 150 capsules, B099C6HF26, sold by Revive MD from its own store. Its text and title still name alpha-GPC from an earlier formula. Accessed Oct 22, 2026. amazon.com
4. McGlade E, et al. Improved attentional performance following citicoline administration in healthy adult women. Food Nutr Sci, 2012. Cognizin at 250 or 500 mg a day for 28 days, 60 women aged 40 to 60. doi.org
5. Darbinyan V, et al. Rhodiola rosea in stress induced fatigue. A double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine, 2000. 170 mg a day for two weeks, 56 physicians. PMID 11081987
6. Ostadmohammadi V, Raygan F, Asemi Z. Alpha-lipoic acid administration affects psychological status and markers of inflammation and oxidative damage in patients with type 2 diabetes and coronary heart disease. J Diabetes Metab Disord, 2022. 600 mg a day for 12 weeks, 60 patients, lower depression scores. PMID 36404866
7. Revive MD. Brain+ finished product certificate of analysis, signed Aug 14, 2025, with the lab, manufacturer and lot blacked out. Measures folate 226 mcg DFE and vitamin B12 (printed "696 mg/serv"), gluten under 5 ppm, microbes and heavy metals (lead 0.947 ppm). Accessed Nov 10, 2026. revivesups.com
8. Lopresti AL, et al. An examination into the effects of a saffron extract (affron) on mood and general wellbeing in adults experiencing low mood. A randomized, double-blind, placebo-controlled trial. J Nutr, 2025. 28 mg a day for 12 weeks, 202 adults. PMID 40414301
9. Itoh Y, et al. Effect of the antioxidant supplement pyrroloquinoline quinone disodium salt (BioPQQ) on cognitive functions. Adv Exp Med Biol, 2016. 20 mg a day for 12 weeks, 41 older adults. PMID 26782228
10. Yang Y, et al. A multicenter, randomized, double-blind, placebo-controlled clinical trial for efficacy of acetyl-L-carnitine in patients with dementia associated with cerebrovascular disease. Dement Neurocogn Disord, 2018. 500 mg three times a day for 28 weeks, 56 patients. PMID 30906386
11. Colzato LS, Jongkees BJ, Sellaro R, Hommel B. Working memory reloaded. Tyrosine repletes updating in the N-back task. Front Behav Neurosci, 2013. A single 2.0 g dose. PMID 24379768
12. Revive MD. Refund policy. Returns within 15 days of purchase, in new condition with the original packaging and a return authorization number, sale items excluded, buyer pays return shipping. Accessed Nov 10, 2026. revivesups.com/policies/refund-policy
13. Roberto M. Revive MD Brain+, a whole brain health nootropic supplement. PricePlow, Apr 5, 2021. Lists a choline blend of 600 mg alpha-GPC 50% and 250 mg citicoline, plus phosphatidylserine. Accessed Nov 10, 2026. priceplow.com
14. MedlinePlus. Lithium. Prescribed to treat and prevent episodes of mania in bipolar disorder, usually taken three to four times a day, with regular blood tests. Last revised Apr 15, 2017. Accessed Nov 10, 2026. medlineplus.gov